Lake Nona Community Profile
Lake Nona spans 17 square miles (about 11,000 acres) in southeast Orlando (zip 32827) — contiguous to Orlando International Airport (about a 10-minute drive) and roughly 20 minutes from downtown Orlando. Its 650-acre Medical City health and life sciences hub grew from UCF’s first medical students in 2009 to a projected 30,000 jobs and a projected $7.6 billion economic impact. The median home sale price in Lake Nona was $709,758 over the trailing 3 months as of July 2026 — down 11.1% year-over-year.
Sources: Lake Nona Fact Sheet · Lake Nona Medical City (Wikipedia) · Redfin — Lake Nona housing market
Employment Base
1.2 million sq ft campus with roughly 370 operating beds, including a 120-bed community living center. Opened in 2015 as the first brand-new VA medical center in Florida in nearly two decades, and now the 4th-largest VA medical center in the U.S. It also houses the National SimVET Center (~52,000 sq ft), the VA's largest medical-training simulation facility.
Read more130-bed hospital opened in 2012 on nearly 60 acres. Now undergoing a $300 million, four-year expansion: a 110,000 sq ft pediatric hospital addition (doubling the ER, adding beds and imaging, opening 2028), a 75,000 sq ft patient care center with six new ORs (2028), and 75,000 sq ft of support infrastructure plus an 800-space parking garage (2027).
Read moreAnchors the academic side of Medical City's 8-institution health and life sciences hub.
Read more63 acres with 100 outdoor tennis courts — the largest tennis facility in the country. It's the USTA's "Home for American Tennis," with partnerships with UCF, Visit Orlando, and Visit Florida for national and international tournaments.
Read moreA $400 million learning, development and innovation facility — KPMG's largest capital investment ever, with Lake Nona chosen over 48 other cities evaluated.
Read moreHealthcare Capacity
AdventHealth Lake Nona, billed as a “hospital of the future,” recently topped out (reached full structural height). A medical office building opens October 2026 and the hospital opens November 2026, with roughly 600 physicians, nurses, and support staff at launch.
It will offer cardiology, orthopedics, labor and delivery, urology, gastroenterology, general surgery, cancer care, bariatrics, and neurology, including “The Baby Place” with 10 labor and delivery rooms and 15 postpartum rooms, and an adjacent cancer care medical office building. It’s designed to serve a fast-growing area with a documented shortage of 124 primary care physicians and 145 specialists.
Read moreAmenity Growth
Lake Nona already has a large, established everyday-retail and grocery base on top of what’s newly opened — the area is built out today, not just “coming soon.”
A new retail district that opened July 2026, anchored by a nearly 150,000 sq ft Super Target (newer, larger format), plus Homesense (full furniture galleries), Barnes & Noble, and Total Wine & More — all currently trading.
Read moreOpened June 12, 2026 at 10013 Eagle Creek Sanctuary Boulevard (corner of Eagle Creek Sanctuary Blvd and Narcoossee Road), roughly 23,299 sq ft, anchoring a ~81,250 sq ft retail development with additional restaurants, shops, and office space.
Read moreGrocery
Major Retail
Pharmacy
Dining
Why This Matters for Investors
Medical City’s projected 30,000 jobs put a large, credentialed workforce inside a 17-square-mile footprint — physicians, nurses, researchers, faculty, and corporate staff at KPMG Lakehouse. That is the kind of tenant base that keeps rental demand steady through softer stretches in the wider Orlando market.
New healthcare capacity compounds it: AdventHealth Lake Nona opens in November 2026 with roughly 600 staff at launch, and Nemours is adding $300 million of expansion through 2028. Retail and dining follow the payroll — Lake Nona West (opened July 2026) brings a nearly 150,000 sq ft Super Target plus national retail, on top of an already established grocery and everyday-retail base, which is the amenity layer that lifts what a household will pay to live there.
Compared with other Orlando submarkets, that combination — a concentrated employment anchor, expanding hospital capacity, and a maturing retail core — is why Lake Nona carries a higher entry price ($709,758 median as of July 2026, down 11.1% year-over-year) and a different appreciation profile than the county-level averages. Underwrite the submarket, not the metro.
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